Concise total synthesis of (+)-gliocladins B and C
نویسندگان
چکیده
منابع مشابه
Concise Total Synthesis of (+)-Gliocladins B and C.
The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel-Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3'-indolyl)hexahydropyrroloindole substructure, a molecular foundation present in a significant subset of epipolythiodiketopiperazine natural alkaloids. Our first-gen...
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Introduction. – The styryl lactones have become a hot topic of phytochemistry and oncopharmacology after taxol. The genus Goniothalamus (Annonaceae) comprises a broad spectrum of styryl lactones, and its species were widely used as traditional medicines in China as antalgic and pesticide agents [1]. The extract of the seeds of Goniothalamus amuyon has been employed for the treatment of edema an...
متن کاملConcise total synthesis and structural revision of (+)-pestalazine B.
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline as the key step. Although its structure was confirmed by X-ray analysis, the spectroscopic data did not match those of the natural product. The versatility of the methodology allowed the prepara...
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The concise and efficient total synthesis of (+)-bionectins A and C is described. Our approach to these natural products features a new and scalable method for erythro-β-hydroxytryptophan amino acid synthesis, an intramolecular Friedel-Crafts reaction of a silyl-tethered indole, and a new mercaptan reagent for epipolythiodiketopiperazine (ETP) synthesis that can be unravelled under very mild co...
متن کاملA concise total synthesis of (±)-cipadonoid B from synthetic azedaralide.
The tetranortriterpene cipadonoid B was efficiently constructed from synthetic azedaralide in a one-pot cascade, via the underutilised ketal-Claisen rearrangement.
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2012
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c2sc20270k